Synthesis, characterization and electrochemical monitoring of drug release properties of dual stimuli responsive mesoporous GdPO4:Eu3+ nanoparticles

Abstract

The drug loading and release properties of Eu3+ doped GdPO4 nanoparticles (NPs) were studied using a simple electrochemical protocol in an in-vitro environment, taking acetaminophen as a model drug. The electrochemical monitoring of drug release was also validated with absorption spectroscopy technique. For this purpose, dual stimuli (pH and temperature) responsive monoclinic mesoporous GdPO4 nanoparticles of size ∼22 nm were synthesized by a simple hydrothermal method. Crystal structure, size, shape, morphology, porosity, optical property and magnetic properties of the obtained product were studied by different characterization techniques. Successful loading of drug in NPs was investigated by Fourier transform infrared spectroscopy (FT-IR). Photoluminescence (PL) measurement shows orange-red color emission corresponding to 5D0→7F2 transitions of Eu3+ ions. The vibrating sample magnetometer (VSM) measurements showed negligible hysteresis in both samples, suggesting retention of the superparamagnetic behavior of GdPO4 NPs. The high loading capacity of 79% and encapsulation efficiency of 83% is observed when acetaminophen, an anti-fever drug, was loaded on these mesoporous GdPO4 NPs. The drug was attached on NPs surfaces via absorption, without any special surface modification. During drug release studies, a spontaneous and smooth release from these mesoporous NPs was observed at a moderate-high temperature (37 °C) and low pH (pH 5) with no sign of burst release. These nanoparticles were capable of targeting and specific release of the loaded drug in response to pH and temperature and hence may serve as a potential drug carrier for in-vivo applications.