Abstract
This research included loading of drugs (ibuprofen, ketoprofen, and fenoprofen) on a chitosan polymer to produce drug-loading polymer by entering the chitosan in a Schiff base reaction to protect -NH2 group, the reacting of the product with drug chloride. The prepared compounds were identified spectroscopically, by using infrared spectroscopy, 1H-NMR, and 13C-NMR. The thermal stability of chitosan was measured by using differential scanning calorimeter (DSC) and Differential thermal analysis (DTA). The drug release of ibuprofen, ketoprofen, and fenoprofen from chitosan in hypothetical stomach fluid was studied. The drug concentration that was released in stomach fluid several times was determined by measuring the absorbance in ultraviolet (UV) spectroscopy.
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