Abstract
Two mixed ligand complexes [Ru(bpy) 2(DMHBT)]Cl 2( 1) and [Ru(phen) 2(DMHBT)]Cl 2 ( 2) (where DMHBT is 11,13-dimethyl-13H-4,5,9,11,14-hexaaza-benzo[b]triphenylene-10,12-dione) have been synthesized and characterized by electrospray ionization (ESI) mass, 1H- 1H correlation spectroscopy (COSY), electronic spectroscopy, fluorescence spectroscopy and cyclic voltammetry. Spectroscopic titration and viscosity changes of calf thymus (CT)-DNA in the presence of incremental amount of complexes 1 and 2 clearly demonstrate that both these complexes bind intercalatively to DNA, with binding constant 2.87 ± 0.20 × 10 4M −1 and 1.01 ± 0.20 × 10 5M −1 for complexes 1 and 2, respectively. All the experimental evidences suggest that the ancillary ligand 2,2′-bipyridine (bpy) and 1,10-phenanthroline (phen) influences the intercalative binding of these complexes to DNA.
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