Synthesis, Characterization, and DNA‐Binding Studies of Mononuclear Copper(II)–Phenanthroline–Tyrosine Complex

Abstract

The mononuclear complex [Cu(II)(phen)(L-Tyr)(H(2)O)] was synthesized and structurally characterized by elemental analysis, magnetic susceptibility, UV/VIS, IR, and EPR spectroscopy, and ESI mass spectrometry. The electronic and EPR spectral data suggest a square-pyramidal geometry around Cu(II). Absorption spectra, thermal denaturation, and fluorescence-spectroscopic studies were conducted to assess the interaction of the Cu(II) complex with calf thymus DNA (CT DNA). The intrinsic binding constant for CT DNA/complex (K(b)=3750 M(-1)) and Stern-Volmer quenching constant (K=0.39) were determined.