Abstract
A platinum(II)-DMSO complex has been incorporated into a thymidine based nucleoside through an N-3 pendant pyridyl nitrogen. Electrospray TOF-MS, 1H, 13C and 195Pt NMR methodologies all confirm the new structure. The complex exhibits differential stability in various media with DMSO solutions particularly unstable. Incubation of the complex with pUC18 circular plasmid DNA, followed by gel electrophoresis shows the formation of linearized forms of DNA at 5:1 DNA base pair to complex ratio.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
