Abstract
In this study, multifunctional Fe3O4@SiO2@GdVO4:Dy3+ nanocomposites were successfully synthesized via a two-step method. Their structure, luminescence and magnetic properties were characterized by X-ray diffraction (XRD), scanning electronic microscope (SEM), transmission electron microscopy (TEM), photoluminescence (PL) spectra and vibrating sample magnetometer (VSM). The results indicated that the as-prepared multifunctional composites displayed a well-defined core-shell structure. The composites show spherical morphology with a size distribution of around 360 nm. Additionally, the composites exhibit high saturation magnetization (20.40 emu/g) and excellent luminescence properties. The inner Fe3O4 cores and the outer GdVO4:Dy3+ layers endow the composites with good responsive magnetic properties and strong fluorescent properties, which endow the nanoparticles with great potential applications in drug delivery, magnetic resonance imaging, and marking and separating of cells in vitro.
Highlights
In recent years, controlled drug delivery systems for modern drug therapy have been attracting increasing attention because they exhibit low toxicity, a wide therapeutic window, and ideal drug efficacy as compared to conventional drug delivery systems [1,2]
The multifunctional nanocomposites combine with magnetic and luminescent properties in one entity, and they have attracted great attention in recent years owing to their potential application in the biotechnology and nanomedicine fields including magnetic resonance imaging (MRI), cell separation, drug delivery agents, cell separation, labeling, and optical probes [3,4,5]
If the lanthanide-doped nanomaterials are in direct contact with Fe3 O4, their luminescence may be decreased as the direct contact can cause fluorescence-quenching [13,14,15]
Summary
In recent years, controlled drug delivery systems for modern drug therapy have been attracting increasing attention because they exhibit low toxicity, a wide therapeutic window, and ideal drug efficacy as compared to conventional drug delivery systems [1,2]. The multifunctional nanocomposites combine with magnetic and luminescent properties in one entity, and they have attracted great attention in recent years owing to their potential application in the biotechnology and nanomedicine fields including magnetic resonance imaging (MRI), cell separation, drug delivery agents, cell separation, labeling, and optical probes [3,4,5]. In the choice of luminescent nanomaterials for labeling, targeting and imaging, lanthanide-doped nanomaterials possess many of advantages such as high fluorescence quantum yields, low toxicity, long lifetimes, and high stability in comparison to quantum dots and organic dyes [5,6,7,8]. There have been some reports of constructing multifunctional nanomaterials that were made up of Fe3 O4 and lanthanide-doped nanomaterials. A SiO2 mid-layer between Fe3 O4 and lanthanide-doped nanomaterials is needed
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