Abstract
A new series of substituted aromatic thiazolidinones [1-4]were synthesized by the reaction of acetophenone and its derivatives [5-8]with hydrazine hydrate and merceptoacetic acid in absolute ethanol in one pot manner. The striking feature of this reaction is the formation of hydrazone in situ which in turn undergoes the cyclization with mercepto acetic acid, leading to the formation of new thiazolidinones. Thus, the thiazolidinone ring closes at carbonyl carbon, by the attack of sulfur of mercaptoacetic acid moiety, preferentially from the front (I², axial) so that the nitrogen has an equatorial orientation (I±, equatorial) to avoid steric repulsion, giving minimum steric hindrance. The new compounds were characterized by spectral (IR, 1H NMR,13C NMR, MS) and analytical methods. The new compounds were screened for cytotoxicity (MTT assay) as well as genotoxicity (Comet assay) studies against different cancer cell lines, during which the new compounds depicted potential anticancer behaviour.
Highlights
Severe acute respiratory syndrome (SARS) is a disease triggered by Coronaviruses (CoV)
The principal human receptor of the virus is the angiotensin-converting enzyme 2 (ACE-2) was first recognized in 2003 and the replication strategy was characteristic of the coronavirus subfamily which reduces the number of lymphocytes circulating in the blood in an infected patient [2]
Covid-19 is a class of severe acute respiratory syndrome with high transmission power
Summary
Severe acute respiratory syndrome (SARS) is a disease triggered by Coronaviruses (CoV). The disease is often associated with mild-severe illness based on severity and the initial symptoms experienced within 2-14 days incubation period of the virus in the host cells. A series of SARS and middle east respiratory syndrome (MERS) outbreaks that directly affect human respiratory and pulmonary tracts have been witnessed in the past years. In December 2019, an unusual sickness resulting from a new strain of coronaviruses was identified and after series of studies on the genomic structure and replication of the virus, it was identified to belong to a class of novel β-coronaviruses [3]. No tangible form of medication has been discovered as a permanent drug/vaccine to inhibit the viral growth and replication in human cells, scientists and researchers all over the world are still working tooth and nail for a befitting solution
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