Abstract
Two Ru(II) polypyridyl complexes [Ru(phen)2(idpq)](ClO4)2 (1) and [Ru(dmp)2(idpq)](ClO4)2 (2) were synthesized and characterized. Cytotoxicity, apoptosis, cell cycle arrest, reactive oxygen species and mitochondrial membrane potential were assayed. The IC50 values of complexes 1 and 2 toward HepG-2, A549, MG-63 and HeLa cell lines range from 15.1±2.1 to 24.8±2.4μM. The complexes can effectively induce apoptosis and induce cell cycle arrest at G0/G1 phase by an increase of 4.88% for 1 and 6.64% for 2 at G0/G1 phase in HeLa cells. Complexes 1 and 2 can enter the cytoplasm and accumulate in the nuclei. The complexes can enhance the level of reactive oxygen species. The ratio of the red/green is 0.74 and 0.52 for complexes 1 and 2, which suggests that the complexes induce a decrease of mitochondrial membrane potential. These complexes induce apoptosis in HeLa through ROS-mediated mitochondrial dysfunction pathway.
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