Abstract
Three new chlorido-substituted hydrazone compounds N′-(3,5-dichloro-2-hydroxybenzylidene)benzohydrazide (H2L1), N′-(3,5-dichloro-2-hydroxybenzylidene)-4-fluorobenzohydrazide (H2L2) and N′-(2-hydroxy-3-methylbenzylidene)-4-trifluoromethylbenzohydrazide (H2L3), were prepared and characterized by IR, UV–Vis and 1H NMR spectra. Based on the hydrazone compounds, three new vanadium(V) complexes, [VOL1(OEt)(EtOH)]·[VOL1(OEt)(MeOH)] (1), [VOL2(OEt)(EtOH)] (2) and [VOL3(OEt)(EtOH)] (3), were prepared and characterized by IR and UV–Vis spectra, as well as single crystal X-ray diffraction. X-ray analysis indicates that the complexes are mononuclear vanadium(V) species, with the V atoms coordinated in octahedral geometry. The hydrazone compounds and their vanadium complexes were evaluated against the bacteria Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence, and the fungi Candida albicans and Aspergillus niger. The existence of the fluoro groups in the hydrazone ligands can improve the antibacterial activities.
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