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Abstract
New isonicotinohydrazone compounds, N’ -(3-bromobenzylidene)isonicotinohydrazide ( 1 ) and N’ -(2,3-difluorobenzylidene)isonicotinohydrazide ( 2 ), were prepared and structurally characterized by elemental analysis, IR, UV and 1 H NMR spectra, and single crystal X-ray determination. Compound 1 crystallizes in the monoclinic space group P 2 1 / n with unit cell dimensions a = 7.600(2) A, b = 11.365(2) A, c = 14.412(2) A, β = 101.748(2)o, V = 1218.7(4) A 3 , Z = 4, R 1 = 0.0335, and wR 2 = 0.0745. Compound 2 crystallizes in the triclinic space group P -1 with unit cell dimensions a = 7.6241(6) A, b = 11.3937(9) A, c = 14.335(1) A, α = 79.664(1)o, β = 75.990(1)o, γ = 71.159(1)o, V = 1136.5(2) A 3 , Z = 4, R 1 = 0.0345, and wR 2 = 0.0940. Structures of both compounds are stabilized by hydrogen bonds and π···π interactions. KEY WORDS : Isonicotinohydrazone, Crystal structure, Hydrogen bonds, X-ray diffraction Bull. Chem. Soc. Ethiop. 2018 , 32(1), 125-132 DOI: https://dx.doi.org/10.4314/bcse.v32i1.11
Highlights
Isonicotinohydrazide is a well known anti-tuberculosis drug
Compound 2 crystallizes in the triclinic space group P-1 with unit cell dimensions a = 7.6241(6) Å, b = 11.3937(9) Å, c = 14.335(1) Å, α = 79.664(1)o, β = 75.990(1)o, γ = 71.159(1)o, V = 1136.5(2) Å3, Z = 4, R1 = 0.0345, and wR2 = 0.0940. Structures of both compounds are stabilized by hydrogen bonds and π···π interactions
It can react with aldehydes to form isonicotinohydrazones, which show interesting biological activities [1,2,3,4]
Summary
Isonicotinohydrazide is a well known anti-tuberculosis drug. It can react with aldehydes to form isonicotinohydrazones, which show interesting biological activities [1,2,3,4]. N’-(3-bromobenzylidene)isonicotinohydrazide (1) and N’-(2,3-difluorobenzylidene)isonicotinohydrazide (2), were prepared and structurally characterized by elemental analysis, IR, UV and 1H NMR spectra, and single crystal X-ray determination. Compound 1 crystallizes in the monoclinic space group P21/n with unit cell dimensions a = 7.600(2) Å, b = 11.365(2) Å, c = 14.412(2) Å, β = 101.748(2)o, V = 1218.7(4) Å3, Z = 4, R1 = 0.0335, and wR2 = 0.0745.
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