Abstract
The structure of title compound Negundoside (2′-p-hydroxybenzoyl mussaenosidic acid) was established by spectral and X-ray diffraction studies. The compound crystallizes in the monoclinic crystal system with space group P21 having unit cell parameters: a=11.6201 (5) Å, b=9.2500 (4) Å, c=12.2516 (5) Å, β=97.793 (4)°, and Z=2. The crystal structure was solved by direct method using single crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedures to a final R value of 0.0520 for 3389 observed reflections.
Highlights
Vitex negundo Linn is widely used in the indigenous system of medicine in India
The molecule consists of four rings in which two are condensed rings
The bond angles around the carbon atom C7 (i.e., O3–C7–C8 = 111.5 (3)∘, O3–C7–O4 = 123.3 (3)∘, and O4–C7–C8 = 125.2 (3)∘) and carbon atom C23 (i.e., C21–C23–O9 = 119.4 (3)∘, C21–C23–O10 = 115.7 (3)∘, and O9–C23–O10 = 124.8 (3)∘) are close to 120∘ which shows that these two carbon atoms are in sp2 hybridized state
Summary
Vitex negundo Linn (family: Verbenaceae) is widely used in the indigenous system of medicine in India. The plant is reported to have anti-inflammatory and antiarthritic properties [2]. Five iridoid glycosides have been reported from the leaves of V. negundo; these are aucubin, agnuside [9], negundoside, and nishindaside [10]. A number of pharmacological properties have been attributed to V. negundo including snake venom neutralization [12], hepatoprotective [13], tyrosinase inhibition [14], antiandrogenic [15], antifeeding [16], antifungal [17], analgesic, anti-inflammatory [18], central nervous system activity [19], mosquito repellent [20], nitric oxide scavenging [21], antiradical, antilipoperoxidative [22], antibacterial [23], and larvicidal [24]
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