Abstract
A series of bidentate pyrrole-imine ligands, [C4H3NH-(2-CH=N-R)] (1, R = cyclohexenyl; 2, R = CH2CH2-1-cyclohexenyl; 3, R = tBu; 4, R = CH2-2-furyl; 5, R = 2-methoxylphenyl; 6, R = phenyl; 7, R = 3-nitrophenyl; 8, R = 2,6-di-isopropylphenyl; 9, R = 2,4,6-trimethylphenyl), were synthesized and their corresponding ruthenium metal compounds {Ru (ɳ6-p-cymene)[C4H3N-(2-CH=N-R)]Cl} (Ru-1∼Ru-9) were also synthesized. These ligands and ruthenium compounds were all characterized by 1H and 13C NMR spectroscopy and some of their structures are also determined by single crystal X-ray crystallography. The Ru-1∼Ru-9 showed excellent GI50 for PC-3 and DU-145 with the range of 3.83–12.13 and 4.25–11.22 μM, respectively. Among of these ruthenium compounds, Ru-6 has the best activity indicating phenyl ring is the key group on the imine substituents of these ruthenium compounds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
