Synthesis, Characterization and Biomedical Application of Silver Nanoparticles.

Ashwini Naganthran,Siti Aqlima Ahmad,Norazah Mohammad Nawawi,Farah Eryssa Khalid,Che Azurahanim Che Abdullah,Gayathiri Verasoundarapandian,Azham Zulkharnain,Murni Karim,Mas Jaffri Masarudin

doi:10.3390/ma15020427

Abstract

Silver nanoparticles (AgNPs) have been employed in various fields of biotechnology due to their proven properties as an antibacterial, antiviral and antifungal agent. AgNPs are generally synthesized through chemical, physical and biological approaches involving a myriad of methods. As each approach confers unique advantages and challenges, a trends analysis of literature for the AgNPs synthesis using different types of synthesis were also reviewed through a bibliometric approach. A sum of 10,278 publications were analyzed on the annual numbers of publication relating to AgNPs and biological, chemical or physical synthesis from 2010 to 2020 using Microsoft Excel applied to the Scopus publication database. Furthermore, another bibliometric clustering and mapping software were used to study the occurrences of author keywords on the biomedical applications of biosynthesized AgNPs and a total collection of 224 documents were found, sourced from articles, reviews, book chapters, conference papers and reviews. AgNPs provides an excellent, dependable, and effective solution for seven major concerns: as antibacterial, antiviral, anticancer, bone healing, bone cement, dental applications and wound healing. In recent years, AgNPs have been employed in biomedical sector due to their antibacterial, antiviral and anticancer properties. This review discussed on the types of synthesis, how AgNPs are characterized and their applications in biomedical field.

Highlights

Nanotechnology is one of the fastest growing field and its application can be applied in various industry sectors
The results showed that biosynthesized AgNPs showed an effective antibacterial activity against S. aureus, K
The biosynthesized AgNPs can be beneficial as a surface coating of conventional dental implants to prevent infections

Summary

Introduction

Nanotechnology is one of the fastest growing field and its application can be applied in various industry sectors. This technology helps to downsize bigger size materials with unique properties to atomic size and these are called nanoparticles (NPs). NPs are particles that ranges between 1 to 100 nm These NPs are unique due to their small size, large surface area to volume ratio, high carrier capacity, high reactivity and easy variation of surface properties [1]. The distinctive properties of smaller-sized AgNPs enable them to be applied in wide range of functions [2]. Silver nanoparticles (AgNPs) have been widely used in agriculture, commercial, medical and industry applications [3]. AgNPs are used as an additive in vaccine adjuvant, anti-diabetic agent, wound and bone healing, biosensors and anticancer therapy in medical applications [4]

Methods

Results

Conclusion