Abstract
The novel homodinuclear zinc(II) complexes with the quinolone antibacterial drugs ciprofloxacine and neutral bidentate ligands have been synthesized and characterized by elemental analysis, TG analyses and various spectroscopic techniques. The metal ion exhibits octahedral geometry with two water molecule in the inner sphere cavity environment. The interaction of complexes with DNA was determined using absorption titration, viscosity measurements and electrophoresis technique. The intrinsic binding constants ( K b ) of complexes were determined, which were ranging from 1.0 × 10 4 to 3.5 × 10 4 per mole. Suggesting that complexes bind more strongly to DNA. Effect on viscosity has also been checked to authenticate the binding of metal complexes with DNA. An antimicrobial activity of all the ligands and metal complexes has been examined by minimum inhibitory concentration method (MIC).
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