Abstract
BackgroundMetal complexes Cu[C13H8O4N]22, Ni[Cl3H8O4N]23, and Co[C13H8O4N]24 of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C13H9O4N] 1.All the complexes are well characterized by various spectral and physical methods. The antimicrobial activity of the complexes has been studied against some of the pathogenic bacteria and fungi.ResultsResults indicate that complexes have higher antimicrobial activity than the free ligand. This would suggest that chelation reduces considerably the polarity of the metal ions in the complexes which in turn increases the hydrophobic character of the chelate and thus enables permeation, through the lipid layer of microorganisms. All the complexes were assessed for their anticancer studies against a panel of selected cancer cells HOP62 and BT474 respectively. Results showed that the complexes are promising chemotherapeutic alternatives in the search of anticancer agents. The fluorescence quenching phenomenon is observed in the Schiff base metal complexes.ConclusionThe octahedral transition metal complexes 2, 3, and 4 have been obtained by treatment of ligand 2-furylglyoxal-anthranilic acid (FGAA) 1 with metal acetate. Complexes under investigations have shown antimicrobial, potential anticancer, and the DNA binding studies.Graphical abstract
Highlights
Metal complexes Cu[C13H8O4N]2 2, Ni[Cl3H8O4N]2 3, and Co[C13H8O4N]2 4 of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C13H9O4N] 1
All the metal complexes were colored, non-hygroscopic in nature, and stable at room temp. They were insoluble in common organic solvents but soluble in Dimethyl formamide (DMF) and dimethyl sulfoxide (DMSO)
A strong band appeared at 1735-1690 cm–1 in the IR spectra of ligand (FGAA) which is due to the presence of stretching vibration of carbonyl group coordination through this carbonyl oxygen to the central metal ion is confirmed by a negative shift in this frequency in the spectra of corresponding metal complexes
Summary
Metal complexes Cu[C13H8O4N]2 2, Ni[Cl3H8O4N]2 3, and Co[C13H8O4N]2 4 of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C13H9O4N] 1. The chemistry of transition metal complexes has received considerable attention largely due to their catalytic and bioinorganic relevance. Such complexes are important due to their potential biological activities such as antibacterial, antifungal, antimalarial, and antitumor [1,2,3,4]. Schiff base constitutes an important class of nitrogen donor ligands and occupy a prominent position among the recent achievement in the field of coordination chemistry. The chemistry of Schiff base metal complexes is exploited in industries, Srivastava Future Journal of Pharmaceutical Sciences
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