Synthesis, Characterization, and Biological Studies of Metal Complexes of Dicoumarol Derivatives of Gatifloxacin

Abstract

Copper(II) complexes were prepared using gatifloxacin and dicoumarin derivatives to investigate their biological activities and to conduct X-ray studies. The complexes were synthesized through classical thermal methods. Biologically potent ligands were synthesized by the reaction of dicoumarin derivative with different aldehydes in ethanol. Cu(II) complexes were formed by mixing ethanolic solution of ligands and gatifloxacin with metal solutions in a 1:1 mole ratio. The structures of the dicoumarin derivatives and their Cu(II) complexes were analyzed by infrared, 1H NMR, 13C NMR, and mass spectrometry. The thermal behavior of the new mixed ligand Cu(II) complexes was investigated by thermogravimetric, fast atom bombardment (FAB) mass, and X-ray analysis. The iron-reducing antioxidant potential (FRAP) (antioxidant activity) of all compounds was evaluated. All the synthesized compounds were screened for antibacterial activity against Escherichia coli; Pseudomonas aeruginosa; Streptococcus pyogenes; minimum inhibitory concentration values for Candida albicans; and Aspergillus niger were determined using the Luria Broth dilution method. The ligands and their complexes were evaluated for antioxidant and antibacterial activity in vitro. The complexes exhibited better results than their respective counterparts.. KEYWORDS :Antimicrobial, Antioxidant, Fast atom bombardment mass, Thermal analysis, Thermo gravimetric analysis, X-ray.