Abstract
Aim: In the present work, we have designed and synthesized indole-fused coumarin derivatives as potential antibacterial and antifungal agents.
 Place and Duration of Study: The present work was carried out at PEA's Modern college of Pharmacy, Sector 21, Yamunanagar, Nigdi- 411044 between the duration of January-2021 to May-2021.
 Methodology: The in vitro antibacterial and antifungal activity was performed by disc diffusion method. The antibacterial activities were tested using agar nutrient medium against Bacillus subtilis, Bacillus pumilus, Escherichia coli, and Pseudomonas aeruginosa that are representative types of gram-positive and gram-negative organisms respectively. The anti-fungal activity of all the compounds were determined on potato dextrose agar medium against Aspergillus niger and Candida albicans. Clotrimazole 100 μg/ml was used as a standard and DMF was used as control.
 Results: It was observed that all the compounds were sensitive to the gram +ve bacteria. Compound 2c, 2e, and 2f were sensitive to gram –ve bacteria. Compounds 2a, 2b, and 2f were sensitive to both the fungal strains while all the derivatives were sensitive to Candida albicans.
 Conclusion: From present investigation it has been observed that compound 2f was sensitive against gram +ve, gram –ve, and both the strains of fungal strains. Structurally, compound 2f possess aldehyde functional group at indole nucleus. Therefore, from present study we have concluded that compound 2f is a lead molecule for the further development of potential antibacterial and antifungal agents.
Highlights
From present investigation it has been observed that compound 2f was sensitive against gram +ve, gram –ve, and both the strains of fungal strains
From present study we have concluded that compound 2f is a lead molecule for the further development of potential antibacterial and antifungal agents
All the synthesized compounds were subjected for antibacterial activity at a 100μg/ml concentration and DMF as a control against, Bacillus subtilis, Bacillus pumilus, Escherichia coli and Pseudomonas aeruginosa by discdiffusion method
Summary
The fact that many pathogenic microorganisms responsible for a variety of human and animal diseases have developed mechanisms of resistance to conventional therapies has prompted extensive research in the fields of natural and synthetic chemistry with the goal of discovering new drug classes with significantly improved therapeutic profiles than those currently available [1]. In this regard, the antimicrobial activities of numerous classes of organic substances, including phenols [2,3], coumarins [4,5,6,7,8], thiophenes [9], quinones [10], and azo compounds [11], are currently the focus of drug discovery efforts around the world. Combining two or more potentially bioactive substructures to form an integrated new molecular framework with increased anticipated therapeutic firepower is a conceptually simple concept that has proven to be extremely successful in the context of infectious diseases that necessitate effective killing of microbes [1]
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