Abstract
The synthesis, characterization and biological evaluation of two new neutral tricarbonyl fac-M(CO)3(SNO) (M=Re, 99mTc) bearing o-methoxyphenylpiperazine as pharmacophore and S-functionalized cysteine or penicillamine as chelators are reported. Competition binding tests showed good affinity for the 5-HT1A receptor (8 and 54nM for 4a and 4b, respectively). Biodistribution studies in healthy animals showed high initial blood and liver uptake, fast blood and tissue depuration and negligible brain uptake.
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