Abstract
A new Schiff base ligand (L) and its transition divalent metal complexes were prepared by the condensation reaction; Reaction was carried out at 70-80 oC by refluxing equimolar ratio of toluidine and aldehyde by continuous stirring for 5-6 hours. Synthesized ligand and Ni(II), Fe(II), Co(II), Mn(II) and Zn(II) bimetallic complexes were characterized by using FT-IR, UV-visible spectroscopy, AAS, Single crystal X-ray analysis, 1H-NMR, molar conductance. Compounds were screened against two fungus Candida glabrata and Candida albicans by agar tube dilution protocol. In vivo anti-inflammatory activity via induced paw edema method and in vitro results by heat induced protein denaturation method were checked. Synthesized compounds were also showed antioxidant activity by using DPPH (diphenylpicrylhydrazyl) and Trolox was used as standard. These studies show that ligand and almost all metal complexes are reactive towards biological assays against reported standard drugs. Zn-L indicates more activeness for antioxidant activity and free ligand while Co-L recognized as more effective anti-inflammatory drug.
Highlights
Schiff bases were discovered first time by the chemist Hugo Schiff in 1864 [1]. These are condensation products of carbonyl compounds and amines [2], called as imine or azomethine due to (-HC=N-) functional group [3], here nitrogen atom serves as bonding molecule for complexation.In azomethine derivatives, the C‚N linkage is essential for biological activity [4,5], several azomethine have been reported to possess remarkable antibacterial, antifungal, anticancer and antimalarial activities [6,7,8,9]
FT-IR The metal-ligand bond was verified by comparing the IR spectrum of the Schiff base ligand with metal (II) complexes
The FT-IR spectra predicted all the absorption bands of the Schiff base ligand (L) and some new bands at specific frequency confirmed the modes of absorption and the coordination of the ligand (L) with the metal ions through azomethine nitrogen and oxygen
Summary
Schiff bases were discovered first time by the chemist Hugo Schiff in 1864 [1]. These are condensation products of carbonyl compounds and amines [2], called as imine or azomethine due to (-HC=N-) functional group [3], here nitrogen atom serves as bonding molecule for complexation.In azomethine derivatives, the C‚N linkage is essential for biological activity [4,5], several azomethine have been reported to possess remarkable antibacterial, antifungal, anticancer and antimalarial activities [6,7,8,9]. Biological activity probably conferred to them by the strong aromaticity of this ring system, which leads to great in vivo stability and generally, a lack of toxicity for higher vertebrates, including humans. Aside from these activities, Schiff bases have other tremendous applications, they serves as dyes, agrochemicals, chemo sensor, catalyst, chemotherapeutic, anticorrosive, polymer [16,17,18,19,20,21]. Biological evaluation of Schiff base ligand (L) and its transition metal complexes were done by antifungal, antioxidant, and anti-inflammatory activities. Synthesized ligand and related complexes are said to demonstrate dynamic applications in the field of material sciences and medicine
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
