Abstract
Four new complexes derived from adamantly containing hydrazone (APH) ligand with Cu(II) (1), Co(II) (2), Ni(II) (3) and Zn(II) (4), have been synthesized and characterized using different physicochemical methods. The structure of the ligand APH and its copper complex 1 have been established by single-crystal X-ray diffraction direct methods, which reveal that complex 1 has distorted square-pyramidal geometry. Complexes 1–4 are screened against seven human cancer cell lines namely, breast cancer cell lines (MCF7, T47D, MDA-MB-231), prostate cancer cell lines (PC3, DU145) and the colorectal cancer cell line Coco-2, for their antiproliferative activities. Complex 1 has shown a promising anticancer activity compared to the other ones. The structural and spectroscopic analysis of APH and its complexes are confirmed by DFT calculations.
Highlights
The potential of having complexes as anti-cancer agents stemmed from the accidental discovery of the cis Platine, cis-[Pt(II)(NH3 )2 Cl2 ], in the 1960s [1]
The ligand Adamantane-1-carboxylic acid pyridin-2-ylmethylene hydrazide (APH) was obtained via condensation of 2-pyridinecarbaldehyde with adamantane-1-carboxylic acid hydrazide according to published procedures [33,34] as described in Scheme 1
All complexes obtained in good yield from the reaction of the metal chloride salts with ligand APH in refluxing ethanol for appropriate time, as shown in Scheme 2 All complexes were characterized using different spectroscopic techniques
Summary
The potential of having complexes as anti-cancer agents stemmed from the accidental discovery of the cis Platine, cis-[Pt(II)(NH3 ) Cl2 ], in the 1960s [1]. The search was directed towards finding platinum-based complexes, which are less toxic, with a better and wider range of selectivity. As a result of such hunt, a wide range of platinum complexes were introduced, like Pt(II) cisplatin, carboplatin, oxaliplatin and Pt(IV) satraplatine and diazides [4,5]. Complexes hold great applications in the therapeutic and diagnostic of cancer. Gold, copper, nickel, titanium, rhodium, vanadium, cobalt, ruthenium and other metals are being given great attention as potential anticancer agents, due to their unique physiochemical properties [4,6,7]
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