Abstract
Novel 4-Chloro-2-[(1-phenyl-1H-tetrazol-5-ylimino)-methyl] phenol (Cl-PTMP) and its transition metal complexes were synthesized and characterized by FT-IR, 1H-NMR, UV-Vis spectroscopy, Mass spectrometry, TGA and SEM. The pH-metric technique was applied to get an insight of the number of dissociable protons and protonation sites in candidate compound. The pH-Metric studies were also carried out in presence of metal ions to establish the formation of corresponding metal complexes in solution. Further, the metal ligand compositions of Cu (II) and Co (II) complexes were determined spectrophotometrically by employing Job’s continuous variation method. To know the molecular properties in title imine compound suitable for metal ion coordination, the computational studies were carried out by employing HyperChem 7.5 tools. The energies of HOMO and LUMO frontier orbitals and their electron density contour maps were generated with geometry optimized molecule. Biological activity of Cl-PTMP and its metal complexes was investigated by disc diffusion method.
Highlights
Tetrazolederivatives have attracted interest because of their unique structure and their applications as antihyper-How to cite this paper: Palreddy, R., et al (2015) Synthesis, Characterization and Biological Activity Studies on Novel 4Chloro-2-[(1-Phenyl-1H-Tetrazol-5-Ylimino)-Methyl] Phenol and Its Metal Complexes
The results revealed the stoichiometry of metal complex as 1:2 (ML2) (Figure 9)
The organism was spread on nutrient agar (1% beef extract, 1% peptone, 0.5 NaCl and 1.5 agar agar) and 20 μl each of Chloro-2-[(1-phenyl-1H-tetrazol-5-ylimino)-methyl] phenol (Cl-PTMP), Cu (II) and Co (II) complexes with concentration of 1 mg/1ml were inoculated into the wells created on agar plates by using sterile 6 mm diameter well borer
Summary
How to cite this paper: Palreddy, R., et al (2015) Synthesis, Characterization and Biological Activity Studies on Novel 4Chloro-2-[(1-Phenyl-1H-Tetrazol-5-Ylimino)-Methyl] Phenol and Its Metal Complexes. Keeping in view the various applications of tetrazoles and in continuation of work reported earlier, in the present investigation synthesis of 4-Chloro-2-[(1-phenyl-1H-tetrazol-5-ylimino)-methyl] phenol (ClPTMP), characterization, molecular properties and metal ion interaction studies were envisaged. Synthesis of Metal Complexes To the methanolic solution of the metal chlorides, (Cu (II) and Co (II)), the solution of Cl-PTMP in chloroform medium was added drop wise. This mixture was reflux for 10 - 12 hours at 50 ̊C - 60 ̊C. The metal complexes obtained were washed with chloroform and methanol (yield: 85% and 90% for Cu (II) and Co (II) complex respectively with m.p. > 300 ̊C for both)
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