Abstract
An efficient and convenient synthesis of β-lactam/ thiazol derivatives has been achieved by the reaction of acetophenone, substituted aromatic aldehyde and thiourea yield substituted schiff’s bases which further undergo the cyclization in the presence of chloroacetyl chloride, triethyl amine/ZnCl2, thioglycoolic acid. All the synthesized novel derivatives have been established by % of C, N, S elements, FT-IR, 1H NMR and Mass spectral studies. Further in-vitro antimicrobial activity of novel derivatives was carried out against some Gram-positive and Gram-negative bacteria by serial dilution method. The activity of IIIc, IIId, IIc, IId, IIf derivatives showed significant response against the tested microbes.
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