Abstract
Nickel, copper, and zinc complexes of isatin (H 2L 1) and N-methylisatin 3-picolinoyl hydrazone (HL 2), were synthesized and characterized by means of spectroscopic techniques. H 2L 1 and a nickel complex [Ni(L 2) 2] · 2C 6H 14 were also characterized by X-ray diffractometry. Biological studies, carried out in vitro on human leukemic cell lines TOM 1 and NB4, have shown that both ligands and some copper and nickel complexes are active in inhibiting cell proliferation. Compounds H 2L 1, Cu(HL 1) 2 · 2H 2O, Zn(HL 1) 2 · 2H 2O inhibit DNA synthesis and act constantly with time between 0 and 72 h. The cell cycle analysis has highlighted a reduction in the number of cells in phase S of about 40%. The same compounds present only a precocious action on cell line NB4 and therefore their activity is cell target specific.
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