Synthesis, Characterization and Biological Activity of Metal Chelates Based On 8-Hydroxyquinoline and 1, 2, 4-Triazol

Abstract

The present study aims to synthesize a novel ligand namely, 5-((3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)methyl)-8-Hydroxyquinoline (TFMTHQ) by reacting 5-chloromethyl-8-hydroxyquinoline (CMQ) hydrochloride, a versatile derivative of 8-hydroxyquinoline with 3-trifluoromethyl-1-H-1,2,4-triazole. The co-ordinate metal chelates of the ligand TFMTHQ were prepared using divalent metal ions viz., Cu2+, Co2+, Ni2+, Mn2+, Zn2+ and Cd2+ by a simple method. The ligand TFMTHQ and its all metal chelates were duly characterized for elemental content, spectral features, M: L (metal: ligand) ratio, and magnetic moment. The results of electronic spectral studies and magnetic properties indicated octahedral geometry for all the metal chelates. All the synthesized compounds were tested for antibacterial activity against gram positive and gram negative bacteria. Antifungal activity of all the samples was tested against plant pathogens such as Aspergillus Niger (AN), Botrydepladia Thiobromine (BT), Nigrospora Sp. (NS), and Fusarium Oxyporium (FO). The results showed good antimicrobial activity of all the metal chelates.