Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes.

Temitayo Aiyelabola,Johan Jordaan,Idowu Olawuni,David Isabirye,Efere Obuotor,Ezekiel Akinkunmi

doi:10.1155/2017/6426747

Temitayo Aiyelabola, Johan Jordaan + Show 4 more

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https://doi.org/10.1155/2017/6426747

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Abstract

Coordination compounds of 4-hydroxy-3-nitro-2H-chromen-2-one and their mixed ligand complexes with aminoethanoic acid and pyrrolidine-2-carboxylic acid were synthesized by the reaction of Cu(II) and Zn(II) salts in molar ratio 1 : 2 for the coumarin complexes and 1 : 1 : 1 for the mixed ligand complexes, in basic media. The compounds formed were characterized using infrared, Uv-vis spectrophotometric analyses, mass spectrometry, magnetic susceptibility measurements, and EDX analyses. It was concluded that 4-hydroxy-3-nitro-2H-chromen-2-one coordinated as a monobasic ligand for all the complexes; it also coordinated via the carbonyl moiety in the case of the Cu(II) mixed ligand complexes. Similarly it was proposed that the amino acids also coordinated in a bidentate fashion via their amino nitrogen and carboxylate oxygen atoms. The synthesized compounds were screened for their antimicrobial and cytotoxic activities. The complexes exhibited marginal antimicrobial activity but good cytotoxic activity.

Highlights

Coumarins are a group of oxygen heterocyclic compounds which have attracted much attention as a result of their varied pharmacological properties which include antibacterial, anticoagulants, antibiotic, antifungal, anticancer, and antiinflammatory [1,2,3,4,5,6,7,8,9,10]
In more recent times an area of focus of coordination chemists is that of mixed ligand complexes
Screening of the compounds for antimicrobial activity was done at the Pharmaceutics laboratory Obafemi Awolowo University Ile-Ife

Summary

Introduction

Coumarins are a group of oxygen heterocyclic compounds which have attracted much attention as a result of their varied pharmacological properties which include antibacterial, anticoagulants, antibiotic, antifungal, anticancer, and antiinflammatory [1,2,3,4,5,6,7,8,9,10]. The reported widespread applications of the coumarin moiety, amino acids, and their coordination compounds, informed our interest in the syntheses of novel mixed ligand complexes containing hnc and amino acids with the aim of obtaining more potent antimicrobial and cytotoxic agents with possible minimal side effects. In this work we report the syntheses, characterization of Cu(II) and Zn(II) coordination compounds of 4-hydroxy-3-nitro-2H-chromen-2-one and their mixed ligand complexes with aminoethanoic acid (L󸀠) and pyrrolidine2-carboxylic acid (L󸀠󸀠), Figure 1, their antimicrobial activity, and brine shrimp lethality bioassay

Materials and Methods

Syntheses of Coordination Compounds

Results and Discussion

Conclusion