Synthesis, characterization and biodistribution of new 99mTc oxo and nitrido complexes with Bi- and tetradendate unsaturated NS and N 2S 2 Schiff bases derived from 2-aminocyclopentene-1-dithiocarboxylic acid as potential heart imaging agents

Abstract

The synthesis, characterization and 99mTc labelling of unsaturated diamino dithiol ligands with methyl dithiocarboxylate functions: 2-aminocyclopentene-1-dithiocarboxylic methyl ester (H 2L1), N,N′-ethylene bis (methyl 2-aminocyclopentene-1-dithiocarboxylate) (H 2L 2) and N,N′-propylene bis (methyl 2-aminocyclopentene-1-dithiocarboxylate) (H 2L3) are described. Cationic oxo (TcO) and neutral nitrido (TcN) complexes were obtained. Biodistribution studies in rat showed a good heart uptake of 99mTcN-L2 (2% ID at 5 min) with a high heart-to-blood ratio (5.8 at 5 min), but this complex also exhibited high lung and liver uptake.