Abstract
Herein, the conventional method used for β-blocker synthesis is initiated by refluxing biphenyl-2-ol (1) with an epoxy ring (2) in the presence of K2CO3 to obtain 2-[(biphenyl-2-yloxy)methyl]oxirane (3). Compound (3) was then reacted with 99% isopropylamine (4) and various substituted phenols (6a-i) to form 1-(biphenyl-2-yloxy)-3-(propan-2-ylamino)propan-2-ol (5) and 1-(2,6-dimethyl-/4-methoxy- /4-chloro-3-hydroxy-/2,6-dimethoxy-/3,4-dimethyl-/4-amine-/4-bromo/3,4-dinitro-/2,4- dihydroxyphenoxy)-3-(biphenyl-2-yloxy)-propan-2-ols (7a-i), respectively. The synthesized compounds were analyzed by 1H NMR and FTIR spectroscopy to determine their structure and also evaluated for their antifungal activity against Rhizoctonia solani and Aspergillus niger using the food poison technique. From the activity data, it was found that compound 1-(biphenyl-2-yloxy)-3-(propan- 2-ylamino)-propan-2-ol (5) was most active against both the fungi Rhizoctonia solani and Aspergillus niger. The antibacterial activity was also determined against Bacillus species by zone of inhibition method. The compounds (5, 7a-i) were also evaluated for its herbicidal activity.
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