Abstract
Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; <i>N</i>-Salicylidene Alanine, <i>N</i>-Salicylidene Serine, <i>N</i>-Benzalidene Histidine, <i>N</i>-Balzalidene Leucine, <i>N</i>-4-(dimethylamino) benzalidene Phenylalanine, and <i>N</i>-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm<sup>-1</sup>. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (<i>Staphylococcus aureus</i>) and gram negative (<i>Escherichia coli</i>) bacteria.
Highlights
Schiff-base ligands and their bio-active metal complexes have been studied extensively for the past decades for applications in bioinorganic and medicinal chemistry, and the research is ongoing
The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria
We have successfully synthesized and partially characterized Schiff base ligands derived from amino acids
Summary
Schiff-base ligands and their bio-active metal complexes have been studied extensively for the past decades for applications in bioinorganic and medicinal chemistry, and the research is ongoing. Schiff-bases provide potential binding sites for bio-chemically active molecules and are generally synthesized by the condensation reaction between amines and carbonyl compounds (aldehydes and ketones). Schiff-bases are recognized by the presence of an imine or azomethine (C=N) group [1-9]. The presence of nitrogen, oxygen and/or sulphur donor atoms in schiff-bases play an important role in biological systems and can move across the phospholipid layers of membrane by active transport. Schiff-base ligands and their metal complexes have been used industrially as catalysts in the presence of moisture and exhibit a wide range of applications including biological activities such as; anti-fungal, anti-malarial, anti-bacterial, anti-diabetic, anti-cancer, anti-proliferative, antiinflammatory, anti-viral, anti-tumor, etc properties. Development of new chemotherapeutic schiff-base ligands and their metal complexes is attracting a lot of attention
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