Synthesis, Characterization and Applications of Some Transition Metal Complexes of Nucleic Acid Constituents

Abstract

Molecular biology is an important in understanding the interactions between the various systems of a cell, including the interactions between deoxyribonucleic acid and ribonucleic acid, DNA and RNA, respectively and protein biosynthesis, (Figure 1). Bioinformatics or computational biology, is the interdisciplinary research field integrating biology with informatics, and is expected to a huge impact on the bioscientific, bioengineering and medical fields. There are many techniques in bioinformatics for DNA microarray data; how ever, these are mainly divided into fold-change analysis, clustering, classification, gentic network analysis, and simulation [1-3]. The introduction of 2H-, 13C-, and 15N-labeled oligonucleotide building blocks became paramount for structure elucidation of RNA and DNA molecules [4-8]. The pyrimidines (1) and purines (2) are of great importance [9-16], where in our laboratory, numerous papers have been published from the structural and coordination chemistry views [17-87] (Figure 2).