Synthesis, Characterization and Application of Chitosan Coated Magnetite Nanoparticles in Drug Delivery

D Balaji,C.Sarala Rubi,M.Vijay Albert William

doi:10.35940/ijeat.b4665.029320

Abstract

Magnetite nanoparticles were used extensively for various applications. In the present study, magnetite nanoparticles were synthesized and characterized by atomic force microscopy (AFM). AFM images showed that the obtained particles were perfectly spherical. Functionality is afforded to these magnetite nanoparticles by adding biocompatible polymer chitosan during the synthesis. AFM phase image clearly showed that the magnetite core is encapsulated with the polymeric shell. Fourier-transform infrared spectroscopy (FTIR) study showed the chitosan absorption on Fe2O3 nanoparticle surface. The drug sulphamethoxazole was loaded over magnetite nanoparticles and the encapsulation efficiency of drug was calculated at different concentrations of magnetite. The encapsulation efficiency increases with increase in the concentration of magnetite. Thus, an attempt was made in synthesizing drug loaded biopolymer magnetite nanoparticles suitable for targeted drug delivery.

Highlights

Magnetic oxide nanoparticles were extensively investigated due to their vast applications
3.1 Atomic Force Microscopy (AFM) The magnetite nanoparticles were analyzed by atomic force microscopy (AFM) with respect to their size and their size-distribution
The drug sulphamethoxazole and the polymer chitosan were loaded to magnetite nanoparticles by adding 2 mg of drug to 50 μl of magnetite and 950 μl of ethanol was added to the solution

Summary

Introduction

Magnetic oxide nanoparticles were extensively investigated due to their vast applications. Due to their better magnetic properties and lower toxicity, magnetite nanoparticles are mostly preferred for the drug delivery system. The biomedical applications of magnetite nanoparticles include: drug delivery, chemotherapy, magnetofection, hyperthermia, scaffold-based tissue engineering, MRI contrast agents, organ/tissue imaging, theranostic platforms, in vitro bioseparation, bioanalysis, and immunoassays [1-3]. Due to the multifunctional properties of the magnetite nanoparticles, they are able to interact with complex cellular functions. This rapidly growing field requires cross-disciplinary research and provides opportunities to develop multifunctional devices to treat cancer

Methods

Results

Conclusion