SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF NOVEL 26-MEMBER RING [2+2] MACROCYCLES FROM DIAMINE DERIVATIVE AND TEREPHTHALDEHYDE

Abstract

Schiff base macrocycles play a significant role in living organisms with a broad range of pharmaceutical activities. In the present study, a novel series of 26 member macrocyclic compounds were synthesized via recombination of novel diamine and terephthaldehyde. A variety of triaryl diamine derivatives react with terephthaldehyde to efficiently result in a [2+2] macrocyclic Schiff base compounds. The newly synthesized compounds were characterized by UV, IR, NMR and Mass and further confirmed by single crystal x-ray diffraction analysis. The antioxidant activity of all the synthesized compounds were tested by Reducing power activity. The compounds were screened at different concentrations from 50-250 (μg/ml) to check the absorbance of compounds. Among seven macrocycle compounds, compound 4f showed highly significant activity. The result shows that as the concentration of compound increase, the compound showed high significant activity.