Abstract
ObjectiveThe aim of the present work was to synthesize different types of complex compounds of two Schiff base ligands with metal ions by varying pH and solvent during their synthesis. MethodsNew Schiff base ligands formed by the condensation of 3-Aldehydosalicylic acid with equimolar quantity of Isonicotinoyl hydrazide (Isoniazid) and 4-Amino-5-phenyl-3-mercapto-1,2,4-Triazole forming 2-hydroxy-3-(2-isonicotinoyl hydrazones)methyl-benzoic acid and 3-[(3-Phenyl-5-mercepto-1,2,4-triazol-4-yl amino)-methyl-2-hydroxy-benzoic acid respectively. The complexes of metal ions like Cu (II), Zn(II), Ni(II), Co(II) and Cd(II) with Schiff base ligand (LH2) have been synthesized at various pH ranges. All the synthesized Schiff bases and metal complexes were characterized by elemental analysis, FTIR, 1H NMR and mass spectral data. ResultsStudy reveals that the Schiff base ligand involved the donor –COOH, –OH and Nitrogen atom. The ligands LH2 in metal complexes behave as monobasic bidentate at different pH ranges. The Schiff bases and metal complexes were screened for their antifungal and antibacterial activities. ConclusionThe Cu (II) and Zn (II) complexes exhibited higher inhibition against microorganisms than the other metal complexes.
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