Synthesis, Characterization and Antimicrobial studies of N-cyclohexyl acrylamide and 7-methacryloyloxy-4-methyl coumarin copolymers

Abstract

A series of copolymers of N-cyclohexylacrylamide (NCA) and 7-methacryloyloxy-4-methyl coumarin (MACU) were prepared by free radical polymerization using AIBN as initiator in DMF. The copolymer compositions were determined by 1HNMR analysis. The reactivity ratios were determined by linear methods like Finemann-Ross and Kelen-Tudos methods. The value of r1 is less than r 2. So MACU is found to have higher reactivity than NCA. Mean sequence lengths of copolymers were calculated from r1 and r2 values. The product of r1. r2 = 1.1, which is greater than 1 indicates that the copolymers are at random distribution of monomeric unit in the copolymer chain. Thermal studies indicates that the Tg values are higher than the homopolymers of NCA. Antimicrobial studies showed that the copolymers are active against both Bacteria and fungi. However, these copolymers showed excellent antibacterial activity