Abstract
A tridentate Schiff base ligand, (E)-2-(4-dimethylbenzydimino) glycylglycine (glygly-DAB), derived from the condensation of 4-Dimethylaminobenzaldehyde (DAB) and glycylglycine (glygly) together with its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and characterized using various physico-chemical methods including C,H,N elemental analysis, melting point determination, molar conductivity measurement, IR, 1H NMR and UV-Vis. The ligand and metal complexes were screened in vitro for antimicrobial and antifungal activities on four bacterial strains (Staphylococcus aureus, Escherichia coli, Salmonella thyphi and Pseudomonas aeruginosa) and two fungal strains (Candida albicans and Cryptococcus neoformans). glygly-DAB showed remarkable antifungal activities on all the fungal strains and antibacterial activities on one bacterial strain.
Highlights
Schiff bases are an important class of ligands due to their synthetic flexibility, their selectivity, their ability to act as multidentate N- and O-donor ligands and their structural resemblance to natural biological substances [1] [2]
Considerable effort has been devoted to the synthesis, characterization, and antimicrobial properties of metal complexes of Schiff bases derived from amino acids [4] [12] but little attention has been paid to systems involving simple peptides [13]
We report here the synthesis, characterization and antimicrobial activity of a Schiff base derived from the peptide, glycylglycine and 4-Dimethylaminobenzaldehyde and its Co(II), Ni(II), Cu(II) and Zn(II) complexes
Summary
Schiff bases are an important class of ligands due to their synthetic flexibility, their selectivity, their ability to act as multidentate N- and O-donor ligands and their structural resemblance to natural biological substances [1] [2]. Schiff bases have been shown to exhibit a broad range of potential applications because of the diversity observed in their structures [1]-[6]. They are good chelators forming stable coordination compounds with transition metal ions using mostly the imine linkage, characteristic of the Schiff bases [1] [2] [3] [4]. Considerable effort has been devoted to the synthesis, characterization, and antimicrobial properties of metal complexes of Schiff bases derived from amino acids [4] [12] but little attention has been paid to systems involving simple peptides [13]. We report here the synthesis, characterization and antimicrobial activity of a Schiff base derived from the peptide, glycylglycine and 4-Dimethylaminobenzaldehyde and its Co(II), Ni(II), Cu(II) and Zn(II) complexes
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