Abstract
A new Mannich baseN-[morpholino(phenyl)methyl]acetamide (MBA), was synthesized and characterized by spectral studies. Chelates of MBA with cobalt(II), nickel(II) and copper(II) ions were prepared and characterized by elemental analyses, IR and UV spectral studies. MBA was found to act as a bidentate ligand, bonding through the carbonyl oxygen of acetamide group and CNC nitrogen of morpholine moiety in all the complexes. Based on the magnetic moment values and UV-Visible spectral data, tetracoordinate geometry for nitrato complexes and hexacoordinate geometry for sulphato complexes were assigned. The antimicrobial studies show that the Co(II) nitrato complex is more active than the other complexes.
Highlights
Metal chelates of Mannich bases form an interesting class of compounds, which find extensive applications in various fields[1,2]
The synthesis of the Mannich base Mannich base N-[morpholino(phenyl)methyl]acetamide (MBA), which is a bidentate ligand
Infrared spectrum of MBA shows a sharp peak at 3297 cm-1, which may be assigned to the νNH of the secondary amide group[10]
Summary
Metal chelates of Mannich bases form an interesting class of compounds, which find extensive applications in various fields[1,2]. Antimicrobial activities[9] of MBA and their metal complexes, such as CoII, NiII, and CuII were tested in vitro against six bacterial species E.coli, P.aeruginosa, S.typhi, B.subtilis, S. pyogenes, and S.aureus and the fungal species A. niger and A.flavus by disc diffusion method using agar nutrient as medium and gentamycin as control. In the IR spectra[16] of all the MBA complexes (Table 2), the stretching frequencies of C=O and C-N-C bonds are found lowered showing that both carbonyl oxygen and CNC nitrogen atoms are coordinated to the metal ions.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
