Synthesis, characterization and antimicrobial property of novel series of 3-(4-substituted phenyl)-1-(4-((4-morpholino-6-((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl) prop −2-en-1-one conjugates

Abstract

N- hetrocycles s-triazine derivatives having chalcone moiety are important organic compounds due to their significant, medicinal, pharmaceutical, and biological activities. With this consideration in mind a novel series of triazine derivatives were synthesised by base catalysed condensation of ketone with different substituted aromatic aldehydes. The structures of newly synthesised triazine derivatives were confirmed by various spectroscopic techniques such as IR,1H NMR,13C NMR. All synthesised compounds were screened for their antibacterial activity against gram positive (Streptococcus pneumonia, Salmonella typhy) gram negative (Escherichia coli) using Kirby-Bauer method was followed for disk diffusion method using ofloxacin as a reference,antifungal property against (Trichophyton rubrum, Candida albicans) fungi and flucanazole used as a reference while antiviral property against (SARS-CoV-2, hepatitis B)viruses using ofloxacin and acyclovir as a reference. It can be noticed that all synthesised compounds showed good antifungal activity,moderate antibacterial activity, mild antiviral activity.