Abstract
The aim of the current research finding was to synthesize, characterize and antibacterial evaluation of sparfloxacin-mediated noble metal nanoparticles. Noble metal [silver (Ag), and gold (Au)] nanoparticles (NPs), mediated with fluoroquinolone, an anti-bacterial drug [Sparfloxacin, (Sp)], was synthesized by a facile and convenient procedure. Formulated Ag-Sp NPs, and Au-Sp NPs exhibited stability against variation in pH, NaCl solution, temperature, and time. The structural topographies of Ag-Sp, and Au-Sp NPs were determined by fourier transform infrared spectroscopy (FTIR), UV-visible spectroscopy (UV-Vis), scanning electron microscopy (SEM) atomic force microscopy (AFM), and energy dispersive X-ray (EDX). UV-Vis revealed the formulation of NPs by showing typical surface Plasmon absorption maxima at 410 nm for Ag-Sp NPs and 555 nm for Au-Sp NPs. The AFM and SEM analysis ascertained stable mono dispersed Ag-Sp NPs and Au-Sp NPs in the size range of 40-50 nm, and 70-80 nm, respectively. Ag-Sp, and Au-Sp NPs exhibited antibacterial traits against Bacillus subtilis, Staphylococcus aureus, and Klebsiella pneumonia, showing a zone of inhibition (ZOI) ranging from 20±0.98 mm to 24±0.94 mm (Ag-Sp NPs), and 22±0.79 mm to 26±0.92 mm (Au-Sp NPs) at dose of 3 mg/mL.
Highlights
Nanosciences have attained great interest due to the syntheses of metal nanoparticles (NPs)
The structural topographies of Ag-Sp, and Au-Sp NPs were determined by fourier transform infrared spectroscopy (FTIR), UV-visible spectroscopy (UVVis), scanning electron microscopy (SEM) atomic force microscopy (AFM), and energy dispersive X-ray (EDX)
The variation in UV-Vis absorption peaks were considered as the primary indication for the biosynthesis of Ag-Sp NPs and Au-Sp NPs
Summary
Nanosciences have attained great interest due to the syntheses of metal nanoparticles (NPs). Several noble nanomaterials such as silver, gold, mercury, platinum, copper and zinc are employed in the biological, agricultural and biomedical fields (Arvizo et al 2012; Johnson alias Antonysamy et al, 2017). The crystalline nature and morphology of NPs play pivotal role in the parameter of their chemical and physical traits (Coe et al, 2002; Mittal et al, 2016; Rizwan et al, 2020). NPs are highly exploited owing to their unique traits such as drug delivery, antimicrobial, electrical, and catalytic properties (Cuenya 2010; Saravanan, Vemu, and Barik 2011; Mittal et al, 2016)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
