Abstract
Series of thiazolidinone derivatives containing triazole moiety have been synthesized by condensing various substituted aldehydes to form Schiff bases which further reacts with thioglycolic acid undergoes ring condensation to form 3-(3-mercapto-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-4-yl)-2-substituted phenylthiazolidin-4-one followed by reaction with ethyl chloroacetate to form ethyl 2-((4-(2-subtituted phenyl-4-oxothiazolidin-3-yl)-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate. The synthesized compounds were characterized by elemental analysis, fourier-tranform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) and mass spectrometry. All synthesized compounds were evaluated for invitro antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and for antifungal activity against Candida albicans, Aspergillus niger. The results of synthesized compounds showed that T-III, T-IX, T-X, and T-XVIII have antimicrobial activity when compared to standard drugs. The compounds having p-bromo, p-chloro, p-methoxy and p-nitro groups showed potent antimicrobial agent
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