Synthesis, characterization and antimicrobial activity studies of new heterocyclic azo dye derived from 2-amino- 4,5- dimethyl thiazole with some metal ions

Abstract

A novel heterocyclic azo dye ligand 2-[2- (4,5-Dimethyl thiazolyl)azo]- 4-methoxy phenol (DMeTAMP) was prepared by coupling reaction between diazonium salt produced from diazonited 2-amino- 4,5- dimethyl thiazole with 4 –methoxy phenol . The structures of the azo dye ligand and the metal complexes were characterized by elemental microanalyses (C.H.N.S), molar conductance, 1 H and 13 C- NMR, UV–Vis spectroscopy , FT-IR spectroscopy, magnetic susceptibility, thermal analysis (TGA), FESEM , mass spectra and XRD diffraction studies. The results appeared that prepared complexes offered [1:2] metal- ligand ratios and the ligand behaved as a tridentate chelating .The compounds were also tested for their bioactive property such as antibacterial and antifungal . The antioxidant activities of the ligand and Mn(II) complex were examined by using the DPPH radical scavenging method the compounds prove exhibited antioxidant properties of scavenging free radicals. Moreover, the anticancer properties of synthesized azo dye ligand and Mn(II) complexes were carried out against Colon cancer cell (CaCo 2 ) cell lines by MTT assay and results revealed that the prepared compounds exhibited good anticancer property and are very promising candidates for future applications in anti-tumor drugs . The finding indicated that these compounds have special significance in the field of medicine and pharmacy.