Abstract
Some new azo-flavones of 2-(substituted phenyl)-6-(p-tolyldiazenyl)-4 H -chromen-4-ones, have been synthesized in three consecutive main steps. 4-toluidine was used as a diazotizing agent and subjected to coupling reaction with 2-hydroxyacetophenone forming 2-(hydroxyl)-5-[4-methylphenylazo] acetophenone as a key substrate. The prepared starting material reacted with different substituted benzaldehydes affording new 2-hydroxy azo-chalcones which were cyclized by DMSO/I 2 giving the target biological active azo-flavone derivatives. The structures of the newly synthesized products were elucidated by using FT-IR, 1 H-NMR, 13 C-NMR and DEPT-135 spectra. The synthesized flavones were screened with two types of bacteria Escherichia coli gram negative and Staphylococcus aurous gram positive. The results observed a significant effect against gram negative bacteria.
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