Abstract
Synthesis of various piperidine derivatives having important biological and pharmacological potentials has been discussed in the past. In present study we reported the synthesis of benzoyl and sulphonyl derivatives by taking Piperidine-4-carboxamide as principal molecule. These compounds were characterized by various spectroscopic techniques such as NMR, FTIR and Mass spectrometry. Elemental composition was explored using CHN analyzer. Antimicrobial activity study of the synthesized compounds was performed using disc diffusion method. Dissociation constant (pKa) of the synthesized compounds were determined by potentiometric titration method. In addition. The findings of the study predicted good absorption of these newly synthesized compounds. Besides, compound III showed good antifungal activity which can be helpful in pharmacokinetics and pharmacodynamics approaches of antibiotics.
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