Abstract
The pyrazoline pharmacophore is the source of numerous biological activities. The synthesis and biological evaluation of new pyrazoline heterocycles is the first step in the development of new potential drugs. Therefore, ferrocene-containing 1-(thio)acetyl pyrazolines were synthesized to test their in vitro antimicrobial activity. All new heterocycles were characterized by standard spectroscopy methods due to confirmation of the structures. In addition, single-crystal X-ray analyses were performed for three representative pyrazole derivatives. Their electrochemical properties were investigated by cyclic voltammetry indicating a reversible one-electron redox couple originating from the ferrocene/ferrocenium pair. All obtained products were evaluated for their antibacterial and antifungal activity. It has been shown that pyrazolines have slightly better antifungal activity compared with their antibacterial activity.
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