Synthesis, characterization and antimicrobial activity of copper(II) Schiff base adducts of some p-substituted aniline Schiff bases

A O Sobola,R O Shaibu,S A Amolegbe,S Adewuyi,G M Watkins

doi:10.4314/bcse.v35i1.3

Abstract

The synthesis, characterization and antimicrobial activity of Cu(II) complexes of some p-substituted aniline Schiff base ligands have been carried out. The Schiff bases were obtained from salicylaldehyde and o-vanillin. The Cu(II) complexes have been characterized by elemental analysis, conductivity measurement, infrared and electronic spectral data. The complexes were obtained either as metal chelates [Cu(L)2] or Schiff base adducts (CuCl2.2LH).xH2O. The metal chelates were non-electrolytes while the Schiff base adducts exhibited 1:1 or 2:1 electrolytes in methanol. The Cu(II) complexes exhibited slight antimicrobial activity against Escherichia coli ATCC® 8739™*, Staphylococcus aureus subsp. aureus ATCC® 6538™*, Bacillus subtilis subsp. spizizenii ATCC® 6633™* and Candida albicans ATCC® 2091™*. The complexes exhibited significant antifungal activity.  KEY WORDS: Metal Chelates, Schiff bases, Adducts, Cu(II) complexes, Salicylaldimines  Bull. Chem. Soc. Ethiop. 2021, 35(1), 33-42. DOI: https://dx.doi.org/10.4314/bcse.v35i1.3

Highlights

Metal complexes have received overwhelming attention in main group and transition metal chemistry due to the ease of their preparation and structural variability
Schiff base metal complexes exist as metal chelates or as Schiff base adducts
Reaction of salicylaldimine (HSal) type ligands with metal salts could as well result in the formation of Schiff base adducts [10,11,12,13,14] containing the intact ligand moieties

Summary

Introduction

Metal complexes have received overwhelming attention in main group and transition metal chemistry due to the ease of their preparation and structural variability. This study presents the synthesis and characterization of some Cu(II) metal chelates and Schiff base adducts. The Schiff base ligands were prepared from salicylaldehyde or o-vanillin and p-substituted aniline.

Results

Conclusion