Abstract
Pyrazole derivatives have attracted considerable attention in last decade in view of diverse chemotherapeutic potential including anti-cancer. In the present research work some derivatives of pyrazole, 4-(1H-imidazol-1-yl)-5-phenylpyrazolidin-3-one (4a-g), were synthesized by treating the corresponding hydrazones with base in moderate yields. The synthesized derivatives were characterized by FT-IR, 1H NMR and Mass spectroscopy and screened for in vitro antimicrobial activity. The compounds 4c, 4f and 4g showed significant antimicrobial activities.
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