Abstract
Some transition metal complexes of nicotinamide have been prepared and characterized using melting point, conductivity measurement, infrared, electronic, HNMR and atomic absorption spectroscopic methods. . The antibacterial and antifungal studies of the metal complexes and the ligand have been evaluated against Escherichia coli , Staphylococcus and Bacillus subtilis , Aspergillus flavus, Aspergillus niger and penicillum species. It was found that nicotinamide formed stable metal complexes with these metal ions. The analysis of the spectroscopic data shows that nicotinamide act as monodentate, coordinating through the nitrogen atom of the pyridine ring. All the complexes exhibit 4- coordinate geometry. The results of the antimicrobial studies showed that the metal complexes have higher inhibitory activity than the original nicotinamide against the tested bacteria and fungi species. Keywords : Synthesis, Metal complexes, Nicotinamide, Antibacterial, Antifungal
Highlights
In the search for novel vitamins-metal complexes, the modification of existing vitamin by coordination to a metal ion has attracted considerable attention in recent years
Synthesis of Metal complexes: The synthetic procedure described by Obaleye et al (1994) was employed in the synthesis of the complexes. 1.231g (10 mmol) of Nicotinamide was dissolved in 20 ml methanol. 10ml of aqueous solution of 5 mmol of metal salts (M=CoCl2.6H2O, NiCl2.6H2O, MnCl2.4H2O, CuCl.6H2O, ZnCl2 and CuCl2) were added to the Nicotinamide solution
The bacteria species used for this study include Escherichia coli, Staphylococcus and Bacillus subtilis while the fungi species used include Aspergillus flavus, Aspergillus niger and penicillum species
Summary
In the search for novel vitamins-metal complexes, the modification of existing vitamin by coordination to a metal ion has attracted considerable attention in recent years. This has led to lots of study on vitaminmetal complexes, with the hope of improving and enriching the quality of existing vitamins, thereby serving as better substitute as chemotherapeutic agents (Obaleye and Orjiekwe (1993). Very few reports on the synthesis and characterization of nicotinamide have appeared in literature. This article reports the synthesis, characterization and antimicrobial studies of some metal complexes of nicotinamide
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