Abstract
As a renewable, biocompatible, and biodegradable polysaccharide, inulin has a good solubility in water and some physiological functions. Chemical modification is one of the important methods to improve the bioactivity of inulin. In this paper, based on 6-amino-6-deoxy-3,4-acetyl inulin (3), three kinds of Schiff bases of inulin bearing pyridine rings were successfully designed and synthesized. Detailed structural characterization was carried out using FTIR, 13C NMR, and 1H NMR spectroscopy, and elemental analysis. Moreover, the antifungal activity of Schiff bases of inulin against three plant pathogenic fungi, including Botrytis cinerea, Fusarium oxysporum f.sp.niveum, and Phomopsis asparagi, were evaluated using in vitro hypha measurements. Inulin, as a natural polysaccharide, did not possess any antifungal activity at the tested concentration against the targeted fungi. Compared with inulin and the intermediate product 6-amino-6-deoxy-3,4-acetyl inulin (3), all the synthesized Schiff bases of inulin derivatives with >54.0% inhibitory index at 2.0 mg/mL exhibited enhanced antifungal activity. 3NS, with an inhibitory index of 77.0% exhibited good antifungal activity against Botrytis cinerea at 2.0 mg/mL. The synthesized Schiff bases of inulin bearing pyridine rings can be prepared for novel antifungal agents to expand the application of inulin.
Highlights
IntroductionThere are a large number of economic losses caused by plant pathogenic fungi every year [1]
In developing countries, there are a large number of economic losses caused by plant pathogenic fungi every year [1]
It has been reported that Botrytis cinerea (B. cinerea) can cause the grey mold disease which could cause fruits and vegetables to rot after harvesting [2]
Summary
There are a large number of economic losses caused by plant pathogenic fungi every year [1]. It has been reported that Botrytis cinerea (B. cinerea) can cause the grey mold disease which could cause fruits and vegetables to rot after harvesting [2]. Fusarium oxysporum f.sp.niveum (F. oxysporum f.sp.niveum) can cause Fusarium wilt of watermelon [3,4]. Phomopsis asparagi (P. asparagi) can blight the asparagus stems, which has been considered as a great threat to asparagus [5]. Chemical pesticides were widely used to control pathogenic diseases. Abuse of chemical fungicides causes harm to the environment and human health [6]. The demand for developing efficacious, environmentally friendly, and natural alternatives has been growing in recent years
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