Abstract
Six mixed ligand dithiocarbamate Pd(II) complexes ( 1– 6) of general formula [(DT)Pd(PR 3)Cl], where DT = dimethyldithiocarbamate ( 1, 5), diethyldithiocarbamate ( 2, 3), dicyclohexyldithiocarbamate ( 4), bis(2-methoxyethyl)dithiocarbamate ( 6); PR 3 = benzyldiphenylphosphine ( 1), diphenyl-2-methoxyphenylphosphine ( 2), diphenyl- p-tolylphosphine ( 3), diphenyl- m-tolylphosphine ( 4), tricyclohexylphosphine ( 5), diphenyl-2-pyridylphosphine ( 6) have been synthesized and characterised using Elemental analysis, FT-IR, Raman and multinuclear magnetic resonance (NMR) spectroscopy. Compounds 1 and 2 were also characterized by single crystal X-ray diffraction technique (XRD). The XRD study reveals that the Pd(II) moiety has a pseudo square-planar geometry, in which two positions are occupied by the dithiocarbamate ligand in a bidentate fashion, while at the remaining two positions organophosphine and chloride are present. The anticancer activity of the synthesized metallodrugs was checked against DU145 human prostate carcinoma (HTB-81) cells, the IC 50 values indicate that the compounds are highly active against these cells. These Pd(II) complexes also show moderate antibacterial activity against gram positive and gram negative bacteria.
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