Abstract
A novel [Dy4(pytza)5(OH)4(H2O)7Cl]Cl2·4H2O compound based on 5-(4-pyridyl)tetrazole-2-acetic acid (Hpytza) has been designed and prepared. This compound is an unprecedented two dimensional network consisting of a tetranuclear cubic [Dy4(OH)4]8+ secondary building unit (SBU) and tridentate pytza via the pyridine-N and the carboxylate group in a μ1,3-COO syn-syn bridging mode. PEG-5000 (poly(ethyleneglycol-5000)) coated [Dy4(pytza)5(OH)4(H2O)7Cl]Cl2·4H2O nanoparticles (NPs) have good dispersity in distilled water. In vitro study on Hela cells shows that such NPs show high toxicity while Hpytza is non-toxic in nature. Furthermore, such NPs can effectively inhibit the migration of Hela cells even at a low concentration, indicating their potential to inhibit the transfer of tumors in vivo.
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