Synthesis, characterization, and anti-cancer potential study of Ag-MgO nanocomposite

Abstract

An attempt to synthesize Silver-Magnesium oxide nanocomposites using Macrotyloma uniflorum powder as an eco-friendly catalyst through solution-combustion method is performed in this paper. The X-ray Diffraction studies confirmed the cubic nature of both Silver and Magnesium Oxide nanoparticles and the average nano crystalline particle size was obtained to be 45 nm. The SEM studies revealed the flake like development of Ag-MgO nanocomposite. The elemental composition was confirmed by Energy Dispersive X-ray Analysis. The characteristic peaks obtained from UV–Visible spectrum confirms the formation of Silver-Magnesium oxide nanocomposites on observing absorption peaks at 300 and 400 nm. Fourier Transform Infrared Spectroscopy spectrum provided confirmation of Silver-Magnesium oxide nanocomposites. The demonstrated method of synthesis is cost-effective and efficient and finds its potential applications in various areas including anticancer activity, photo catalytic degradation, antibacterial activity. In the present work, the synthesized nanocomposite was tested for anticancer activity. The demonstration was done on H69PR lung carcinoma cells. The fabricated nanocomposite exhibited anticancer activity with cytotoxic effect with reduction of H69PR cells with IC50 value of 190 µg/ml.