Abstract
A significant issue in cancer biology is finding anticancer therapies that effectively kill cancer cells. Through the use of several aldehydes, Schiff bases based on branched poly (p-hydroxy styrene) were created. The branched polymer was first chloroacetylated, then aminated with 1,4-phenylenediamine, and finally, aldehydes reacted with the aminated polymer to produce the Schiff base compounds. Through the utilization of FTIR, TGA, XRD, NMR and elemental analysis, all synthesized Schiff-bases were identified and characterized. Further, the antineoplastic potential of all Schiff bases was evaluated against different cancer cell lines. The results gained from this study indicated that the Schiff base polymers had cytotoxic power against cancer cells depending on cancer cell type and this antiproliferation potency was dose-concentration dependent. Importantly, the prepared S1 Schiff-base polymer showed potent cytotoxicity and was able to trigger the apoptosis and reactive oxygen species (ROS) in MCF-7 cells. Further, it downregulated VEGFR protein expression. The Schiff base polymers would have extensive applications in the biological disciplines. This article is protected by copyright. All rights reserved.
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